Manageable risk factors for progression of HPV-associated cervical intraepithelial neoplasia

Objective: to identify informative markers of the progression cervical intraepithelial lesions low degree. Materials and methods: dynamics results cytological study epithelium, genotyping human papilloma viruses high carcinogenic risk (HPV) with an assessment viral load, immunocytochemical expression protein p16 (p16INK4α), serum folic acid in 90 HPV-positive patients reproductive age was analyzed. 43 (47.8%) who made up group I had regression disease. Group II included 30 (33.3%) disease persistence - no significant changes laboratory instrumental research methods. III 17 out (18.9%) progression. Statistical processing carried using parametric non-parametric analysis methods IBM SPSS Statistics 28.0.1.1 (developed by Corporation), STATISTICA 13.5.0.17 StatSoft.Inc) MedCalc 20.027. Results: factors that significantly distinguish or grade from women are: earlier sexual onset, detection atypical clinically HPV p16INK4a expression, below 3.1 ng/ml. Conclusions: deficiency positive should be considered as a pathogenetically factor for implementation infection into clinical form disease, which is confirmed its correlation LSIL, progressive increase copy HPV, p16INKα expression. The patient management strategy, provides personalized lesions, expands monitoring neoplasias associated HPV.